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Probability curves predicting oral food challenge test (OFC) results based on specific IgE levels are widely used to prevent serious allergic reactions. Although several confounding factors are known to affect probability curves, the main factors that affect OFC outcomes are currently unclear. We hypothesized that an increased total IgE level would reduce allergic reactivity. Medical records of 337...
BackgroundPrevious studies have shown the relationship between club cell secretory protein (Clara) (CC‐16) and respiratory diseases. However, few studies have explored the associations between urine CC‐16 levels and environmental tobacco smoke (ETS) exposure in children. The objective of this study was to evaluate whether ETS exposure is associated with CC‐16 when stratified by asthma status.
MethodsIn...
We established a flow cytometric lymphocyte proliferation test (LPT) for the detection of nickel (Ni) and palladium (Pd) sensitization. Eighty‐one consecutive patients with an indication for patch test (PT) were tested by LPT with Ni (NiSO4) and Pd (Na2PdCl4 and PdCl2) salts. The imprecision of the LPT was low (coefficient of variation 7.2%). Using PT as a diagnostic reference, the sensitivity and...
BackgroundLittle is known about factors which trigger and/or contribute to hereditary angioedema or ACE‐inhibitor‐mediated angioedema including variations in bradykinin type 2 receptor (B2R) expression and activity.
MethodsProtein and mRNA expression of B2R and the increase of intracellular calcium (iCa) in response to bradykinin were monitored in porcine and murine endothelial cells in response...
It remains poorly understood how symptoms in allergic rhinitis are most severe during overnight or early in the morning. The circadian clock consisting of a network of several ‘clock genes’ including Clock drives daily rhythms in physiology. This study showed that allergen‐induced surface CD203c expression on basophils in seasonal allergic rhinitis caused by Japanese cedar pollen exhibited a time‐of‐day‐dependent...
BackgroundWe have shown that mycobacterial antigens and CpG oligodeoxynucleotides downmodulate airway allergic inflammation by mechanisms dependent on T‐cell activation. Here, we investigated the participation of the innate response, particularly the role of MyD88 adaptor, and Fas molecules in the effectiveness of DNA‐HSP65 or CpG/culture filtrated proteins (CFP) immunotherapy.
MethodsMice sensitized...
BackgroundPatients with asthma may be more susceptible to adverse events (AEs) with sublingual immunotherapy tablet (SLIT‐tablet) treatment, such as severe systemic reactions and asthma‐related events. Using data from eight trials of grass SLIT‐tablet in subjects with allergic rhinitis with/without conjunctivitis (AR/C), AE frequencies were determined in adults and children with and without reported...
BackgroundHouse dust contains mite allergens as well as bacterial products such as lipopolysaccharide (LPS). Asthma exacerbations are associated with the level of exposure to allergens and LPS. LPS can potentiate allergen effects in steroid‐naïve patients. Long‐acting β2‐agonists (LABA) were shown to inhibit LPS‐induced bronchial inflammation in healthy volunteers. The aim of this study was to assess...
BackgroundKawasaki disease is a vasculitis most commonly afflicting children <5 years of age. Many autoimmune diseases are associated with up‐regulation of T helper (Th) 17 cells, and down‐regulation Treg cells. Few studies have examined the Th17/Treg expression in Kawasaki disease.
MethodsBlood samples were obtained from 186 children with Kawasaki disease at 24 h before IVIG therapy, followed...
BackgroundHazelnut and peanut are botanically unrelated foods, but patients are often sensitized and allergic to both, for reasons that are not well understood.
MethodsTo investigate molecular cosensitization and cross‐reactivity to peanut in hazelnut‐sensitized individuals, children (n = 81) and adults (n = 80) were retrospectively selected based on sensitization to hazelnut. IgE to hazelnut extract,...
A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly‐sensitization is unknown. Using data from the large multicentre population‐based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly‐sensitization...
The impact of early childhood traffic‐related air pollution (TRAP) exposure on development of asthma and allergies remains unclear. Birth cohort studies are the best available study design to answer this question, but the evidence from such studies has not been synthesized to date. We conducted a systematic review and meta‐analyses of published birth cohort studies to understand the association between...
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